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Potent, selective inhibitor of TGF-βRI, ALK-4, ALK-5, and ALK-7.
Product Name SKU Price Qty
SB431542, 5 mg ST10012
SB431542, 10 mg ST10013
SB431542, 1.3 mL / 10 mM ST10014

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SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. It suppresses TGF-β-induced proliferation of human osteosarcoma cells. SB431542 has been shown to stimulate proliferation, differentiation, and sheet formation of ESC-derived endothelial cells.



Molecular Weight 384.39
Molecular Formula C22H16N4O3
Chemical Name 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide
CAS Number 301836-41-9
PubChem Identifier 4521392
Purity >98% by HPLC analysis
Solubility Soluble in DMSO at 100 mM and ethanol at 10 mM
Reconstitution For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed.
References Laping, N.J., et al. (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 62: 58-64. PMID: 12065755.

Watabe, T., et al. (2003) TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol 163: 1303-1311. PMID: 14676305
Technical Documents ST10012 Technical Data Sheet
ST10013 Technical Data Sheet
ST10014 Technical Data Sheet


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