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Y27632

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Selective ROCK1 (p160ROCK) inhibitor.
Product Name SKU Price Qty
Y27632, 2 mg ST10018
$128.00
Y27632, 10 mg ST10019
$245.00
Y27632, 625 µL / 10 mM ST10020
$128.00
 

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Description

Details

Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human ES cells without affecting their self-renewal properties or pluripotency. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors and to significantly improve cell recovery after cryopreservation.

Details

Details

Molecular Weight 320.26
Molecular Formula C14H23Cl2N3O
Chemical Name (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
CAS Number 146986-50-7
PubChem Identifier 9901617
Purity >98% by HPLC analysis
Alternative Names Y27632 dihydrochloride
Solubility Soluble in DMSO at 50 mM and water at 50 mM
Reconstitution For powder form, reconstitute in DMSO to the desired concentration. For detailed instructions on reconstitution and use in cell culture please reference technical data sheet.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
10 mM Solution: Shipped on dry ice. Store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months when stored as directed.
References Koyanagi, M., et al. (2008) Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res 86: 270-280. PMID: 17828770.

Watanabe, K., et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25: 681-686. PMID: 17529971.

Li, X., et al. (2009) ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells. Hum Reprod 24: 580-589. PMID: 19056770.
Technical Documents ST10018 Technical Data Sheet
ST10019 Technical Data Sheet
ST10020 Technical Data Sheet

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