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SP600125, 5 mg

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Novel and selective JNK inhibitor.
SKU: ST10025

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SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2 and p38β. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia and reperfusion-induced apoptosis.



Molecular Weight 220.23
Molecular Formula C14H8N2O
Chemical Name anthra(1,9-cd)pyrazol-6(2H)-one
CAS Number 129-56-6
PubChem Identifier 8515
Appearance Yellow solid
Purity >99% by HPLC analysis
Alternative Names 1,9-Pyrazoloanthrone
Solubility Soluble in DMSO at 100 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 2.27 mL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Bennett, B.L., et al. (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 13681-13686. PMID: 11717429.

Zhao, Y.F., et al. (2013) Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep 46: 422-427. PMID: 23977991.
Technical Documents ST10025 Technical Data Sheet


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