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Cyclopamine, 2 mg

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Hedgehog pathway inhibitor targeting Smoothened
SKU: ST10026
$125.00
 

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Description

Details

Cyclopamine inhibits the hedgehog signaling pathway by direct inhibition of Smoothened (IC50 = 46 nM). It has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells. Cyclopamine has also been shown to inhibit the growth of human and mouse medulloblastoma cells, and human glioblastoma cells.

Details

Details

Molecular Weight 411.62
Molecular Formula C27H41NO2
Chemical Name (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11, 11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
CAS Number 4449-51-8
PubChem Identifier 442972
Appearance White solid
Purity >99% by HPLC analysis
Alternative Names 11-Deoxojervine
Solubility Soluble in ethanol at 5 mM
Reconstitution For a 5 mM concentrated stock solution, reconstitute the compound by adding 972 μL of ethanol to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Bar, E.E., et al. (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25: 2524-2533. PMID: 17628016.

Berman, D.M., et al. (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559-1561. PMID: 12202832.

Chen, J.K., et al. (2002) Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16: 2743-2748. PMID: 12414725.

D'Amour, K.A., et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24: 1392-1401. PMID: 17053790.

Technical Documents

ST10026 Technical Data Sheet

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