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SB203580, 2 mg

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Selective p38 MAPK inhibitor
SKU: ST10024

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SB203580 is a selective p38 mitogen-activated protein kinase (MAPK) inhibitor (IC50 = 0.3 - 0.5 μM). It displays a 100 to 500 fold selectivity over LCK, GSK-3β and PKBα. SB203580 has been shown to enhance clonal growth of skin epithelial progenitor cells and to stimulate neural stem cell (NSC) proliferation.



Molecular Weight 377.44
Molecular Formula C21H16FN3OS
Chemical Name 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
CAS Number 152121-47-6
PubChem Identifier 176155
Appearance Yellow solid
Purity >96% by HPLC analysis
Alternative Names SB-203580
Solubility Soluble in DMSO at 100 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 530 μL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Borsch-Haubold, A.G., et al. (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J Biol Chem 273: 28766-28772. PMID: 9786874.

Davies, S.P., et al. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105. PMID: 10998351.

Sato, K., et al. (2008) Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J Neurosci Res 86: 2179-2189. PMID: 18338804.

Technical Documents

ST10024 Technical Data Sheet


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