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BIX01294, 2 mg

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Inhibits G9a histone methyltransferase
SKU: ST10030

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BIX01294 is a very specific inhibitor of the G9a (IC50 = 1.9 μM) and G9a-like (IC50 = 0.7 μM) histone methyltransferases which modulates H3K9 levels. It has been shown to enhance reprogramming of mouse embryonic fibroblasts or fetal neural progenitor cells to induced pluripotent stem cells without using c-Myc and Sox2.



Molecular Weight 600.02
Molecular Formula C28H38N6O2.3HCl
Chemical Name 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
CAS Number 1392399-03-9
PubChem Identifier 46945860
Appearance Yellow solid
Purity >99% by HPLC analysis
Alternative Names BIX01294 Trihydrochloride Hydrate
Solubility Soluble in DMSO at 100 mM and water at 100 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 333 μL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Kubicek, S., et al. (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25: 473-481. PMID: 17289593.

Shi, Y., et al. (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5): 568-574. PMID: 18983970.

Shi, Y., et al. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2: 525-528. PMID: 18522845
Technical Documents

ST10030 Technical Data Sheet


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