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Sox2 anti-Human/Mouse Antibody, 100 µL

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The Sox2 or SRY (sex determining region Y)-box 2 transcription factor contains a high motility group DNA-binding domain which functions to bind and open the DNA helix, facilitating the actions of other transcription factors.
SKU: ST11001
$215.00
 

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Description

Details

The Sox2 or SRY (sex determining region Y)-box 2 transcription factor contains a high motility group DNA-binding domain which functions to bind and open the DNA helix, facilitating the actions of other transcription factors. The protein is essential for maintaining the self-renewal and pluripotency capabilities of embryonic stem (ES) cells and therefore is commonly used to characterize stem cell populations. Sox2 is an important functional marker of neural precursor cells and plays a critical role in neuronal differentiation.

Details

Details

Concentration 0.5 mg/mL
Species Reactivity Human, Mouse
Host Rat Monoclonal
Isotype IgG2a, κ
Immunogen Human Sox2 Recombinant Protein
Formulation Phosphate-buffered solution containing 0.09% sodium azide, pH 7.2
Storage and Stability Aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. Stable for 6 months from date of receipt when stored as directed.
Applications Tested Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (FC)
Recommended Dilutions Flow Cytometry 1:100
Immunocytochemistry/Immunofluorescence 1:100
It is recommended that the antibody be titrated for optimal performance for each application.
Alternative Names SRY (sex determining region Y)-box 2
References Cavallaro, M., et al. (2008) Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants. Development 135: 541-557. PMID: 18171687.

Fong, H., et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26: 1931-1938. PMID: 18388306.

Graham, V., et al. (2003) SOX2 functions to maintain neural progenitor identity. Neuron 39: 749-765. PMID: 12948443.

Takahashi, K., et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872. PMID: 18035408.

Technical Documents

ST11001 Technical Data Sheet

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