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Forskolin, 10 mg

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Adenylyl cyclase activator targeting cAMP
SKU: ST10023
$129.00
 

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Description

Details

Forskolin is a cell permeable activator of adenylyl cyclase (IC50 = 41 nM), resulting in higher levels of cyclic AMP (cAMP) in the cell. It has been used to potentiate neuron differentiation as well as maintain human ES cells in a naïve or ground state. Forskolin has been shown to enable chemical reprogramming of mouse embryonic fibroblasts to iPS cells in combination with CHIR99021, Tranylcypromine, Valproic Acid, 3-Deazaneplanocin A, and RepSox.

Details

Details

Molecular Weight 410.5
Molecular Formula C22H34O7
Chemical Name [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-on
CAS Number 1392399-03-9
PubChem Identifier 47936
Appearance White to off-white solid
Purity >99% by HPLC analysis
Alternative Names Colforsin, Coleonol, Boforsin
Solubility Soluble in DMSO at 25 mM
Reconstitution For a 10 mM concentrated stock solution, reconstitute the compound by adding 2.4 mL of DMSO to the entire contents of vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.
Storage and Stability Solid: Shipped at room temperature. Store at -20°C. Stable for 6 months when stored as directed.
Solution: Following reconstitution, store aliquots in tightly sealed vials at -20°C. Avoid repeated freeze-thaw cycles.
References Hanna, J., et al. (2010) Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci USA 107: 9222-9227. PMID: 20442331.

Hou, P., et al. (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341: 651-654. PMID: 23868920.

Kim, S.S., et al. (2005) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport 16: 1357-1361. PMID: 16056139.

Robbins, J.D., et al. (1996) Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J Med Chem 39: 2745-2752. PMID: 8709105.
Technical Documents

ST10023 Technical Data Sheet

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