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Stem Cell Reprogramming

Comprehensive portfolio of reagents for cellular reprogramming

Cellular reprogramming has transformed the field of stem cell biology and created a new source of pluripotent cells for research, drug discovery, and regenerative medicine therapies. Scientists have made huge strides since the breakthrough publications in 2006 describing the first methods to generate induced pluripotent stem (iPS) cells.

Today, many different technologies exist to reprogram somatic cells including chemical methods. ESI BIO offers small molecules and antibodies that are widely used in high impact studies to assist in cellular reprogramming and the targeting of key pathways in stem cell experiments.

Now available: BioLite™ antibodies for live cell identification





Featured Products:

Small Molecules

Small Molecules for Cellular Reprogramming

Small molecules have become powerful tools in the reprogramming process and are playing an exciting role in the development of novel reprogramming techniques. The use of small molecules allow researchers to accurately and specifically regulate metabolic pathways and promote epigenetic modifications with specific regulatory and temporal control over normally complex experiments.

ESI BIO offers a collection of small molecules in convenient formats that enable definitive and reproducible control mechanisms for stem cell biology and reprogramming protocols.

Antibodies

BioLite Antibodies for Cellular Reprogramming

The ability to characterize stem cell populations and to monitor the dynamic changes in gene expression that occur during reprogramming and differentiation is an essential part of all stem cell research. When generating iPS cell lines, early identification of pluripotent colonies can save considerable time and effort. Manually picking colonies based on morphology alone is not always reliable.

BioLite™ antibodies allow for direct immunofluorescent staining of live, unfixed, pluripotent stem cell populations and aid in selecting reprogrammed colonies confirmed by marker expression.

 


  References:

  • Lin, T., et al. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808. PMID: 19838168.
  • Hou, P., et al. (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146): 651-654. PMID: 23868920
  • Miranda, T.B., et al. (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther 8(6): 1579-1588. PMID: 19509260
  • Ying, Q., et al. (2008) The ground state of embryonic stem cell self-renewal. Nature 453: 519-523. PMID: 18497825.
  • Brambrink, T., et al. (2008) Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2: 151-159. PMID: 18371436
  • Draper, J.S., et al. (2002) Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat 200: 249-258. PMID: 12033729


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